I have had issues with both eyes, including laser surgeries in both due to retinopathy and intraocular injections. I have also had a vitrectomy (i.e. surgery) in one.
For me, the worst part was recovering from the vitrectomy as I could not lie flat on my back for three months, bend over, or travel in a plane or over mountains (as changes I air pressure could affect recovery).
I would not worry, though. Even though some of the procedures may cause some discomfort, it is usually short-lived, and the results are always woth it.