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Trusted Contributor
Posts: 1,930
Registered: ‎10-23-2011

ESTRADIOL CREME SIDE EFFECTS

I went to a specialist regarding my pelvic prolapse situation and he prescribed Estradiol creme to help in managing my condition.

 

He said to take a "blueberry sized" amt 3X a week.  He didn't mention any side effects.

 

I haven't had any estrogen in my body for many years.

 

Would be interested in any experiences anyone here has had with side effects from Estradiol? 

 

I am VERY SENSITIVE to "weight gain" as I lost 100 lbs 16 yrs ago and  have kept it off.  I think if I experienced weight gain, it would have a very traumatic affect on me.  Also, other things I'm reading about, like breakthrough bleeding and breast sensitivity have me concerned.

 

I will call my doctor on Monday but wanted to know any real-life experiences women here might be able to share. Thanks!!

Frequent Contributor
Posts: 139
Registered: ‎04-12-2010

Re: ESTRADIOL CREME SIDE EFFECTS

First, I am not a doctor.  But I do use this crème and have for several years 1x weekly.  Unlike oral estrogen, this product is not systemic but will affect the areas where applied.  I have had NO issues with weight gain.  Please ask your doctor so you can be reassured.

Respected Contributor
Posts: 3,971
Registered: ‎03-10-2010

Re: ESTRADIOL CREME SIDE EFFECTS

[ Edited ]

@pdlinda I'm on HRT and have had some breakthrough bleeding but I'm on systemic estrogen (estrogen patch)and newly menopausal. It's common and nothing to worry about if you're under a doctors care and get a workup to make sure nothing nefarious is going on (mine was due to polyps, which I had removed).  

 

It sounds like you are only using the cream vaginally? I'm guessing.

With this form and usage the estrogen isn't absorbed systemically, it stays local to sorta plump up the tissues and help them to work better. You should be fine and not worry about any breakthrough bleeding and breast tenderness and even if you did develop these symptoms (which is unlikely) then they would stop as soon as you stopped the estrogen. 

Good luck!Smiley Happy

 

Edited to say: a little cream applied locally stays "mostly" in this area but "technically" minimal systemic absorption can occur in low to negligible amounts from my research and is considered very safe and helpful....

 

"We can judge the heart of a man by his treatment of animals" -Immanuel Kant

"Once you have had a wonderful Dog, a life without one, is a life diminished"-Dean Koontz
Honored Contributor
Posts: 36,006
Registered: ‎03-09-2010

Re: ESTRADIOL CREME SIDE EFFECTS

It may be considered topical, but a certain amount of it will still go thru the blood stream, usually says that on the website. I was prescribed estrogen cream for dryness years ago and refused it for that reason. We all have to be our own advocates when it comes to our healthcare. 

Honored Contributor
Posts: 36,006
Registered: ‎03-09-2010

Re: ESTRADIOL CREME SIDE EFFECTS

My Mom had what was called uterine prolapse, not sure if that is the same thing, but she had it well under control with use of a pessary. You can look this up if unsure of what that is. 

Respected Contributor
Posts: 3,971
Registered: ‎03-10-2010

Re: ESTRADIOL CREME SIDE EFFECTS

[ Edited ]

@pdlinda 

 

Also, don't worry about weight gain. I actually find my systemic estrogen has no effect on my weight and maybe even helps with it.

 

Locally, you shouldn't notice any affects on your weight.Woman Happy

 

 

 

"We can judge the heart of a man by his treatment of animals" -Immanuel Kant

"Once you have had a wonderful Dog, a life without one, is a life diminished"-Dean Koontz
Respected Contributor
Posts: 3,723
Registered: ‎03-09-2010

Re: ESTRADIOL CREME SIDE EFFECTS

I've been on estrogen cream for years.  I use 1g by applicator twice a week.  I've had no issues whatsoever.  I've seen two different doctors since I've been on it, and both say I can stay on it indefinitely.

Honored Contributor
Posts: 47,109
Registered: ‎08-23-2010

Re: ESTRADIOL CREME SIDE EFFECTS


@pdlinda wrote:

I went to a specialist regarding my pelvic prolapse situation and he prescribed Estradiol creme to help in managing my condition.

 

He said to take a "blueberry sized" amt 3X a week.  He didn't mention any side effects.

 

I haven't had any estrogen in my body for many years.

 

Would be interested in any experiences anyone here has had with side effects from Estradiol? 

 

I am VERY SENSITIVE to "weight gain" as I lost 100 lbs 16 yrs ago and  have kept it off.  I think if I experienced weight gain, it would have a very traumatic affect on me.  Also, other things I'm reading about, like breakthrough bleeding and breast sensitivity have me concerned.

 

I will call my doctor on Monday but wanted to know any real-life experiences women here might be able to share. Thanks!!


 

@pdlinda 

 

While I'm sure you'll get good feedback here, don't neglect good old Google for side effects. 

 

Also, the FDA website also has information on reported side effects.   Not every single possible side effect always shows up in clinical trials, so after the fact people can report what happened to them.  

 

 

Respected Contributor
Posts: 3,971
Registered: ‎03-10-2010

Re: ESTRADIOL CREME SIDE EFFECTS

[ Edited ]

I edited my post above to say that local usage "mostly" stays local not a definite and depends....

 

 

 

"We can judge the heart of a man by his treatment of animals" -Immanuel Kant

"Once you have had a wonderful Dog, a life without one, is a life diminished"-Dean Koontz
Honored Contributor
Posts: 9,134
Registered: ‎03-30-2014

Re: ESTRADIOL CREME SIDE EFFECTS

Seems like there might be a little more going on.  Please have the doctor explain more.

 

I have friends that used the cream and friends who had surgery for prolapse, but they were not ever the same persons.