@Judaline My hands are beginning to lose "fat" as well. I was self conscious until I realized everyone else around my age had the similar issue.
Only if going somewhere "special", I use a lotion and then Bare Minerals powder foundation brushed on lightly. It seems to stick to the lotion. Of course, if you need to wash hands while out, I'm careful to wash finger area only or it begins to come off.
I usually just accept it. They can be improved by getting filler between the veins to plump that area, but that's not for me.