I have GERD, a hiatal hernia and Schatzki's ring and for years I have taken one of the PPIs, change about Nexium, Prilosec, etc, as well as Carafate (sucralfate). I can omit the Carafate from time to time but if I have to take additional aspirin, Aleve or other medications that irritate the gut, I get back on a dose of 4 per day, meals and bedtime.