Meta-Analysis: High-Dosage Vitamin E Supplementation May Increase All-Cause Mortality

JeanLouiseFinch · ‎10-03-2011

@1Professor wrote:
@JeanLouiseFinch wrote:
I've read that an reasonable dosage is 200 mg. Unless specific health concerns require more. We take 200 mg. of Qunol Kaneka Ubiquinol daily. They come on 100mg. so we take two. I've read that the Kaneka form is preferred.
@JeanLouiseFinch

Is it this one? Great information about Kaneka!

Yes, @1Professor, that's correct, but we use the Qunol brand.

poregirl · ‎03-09-2010

beware of extra vitamin E in any product. It contributes to all mortality. I avoid it like the plague.

"The most recent published clinical trial of vitamin E and men’s cardiovascular health included almost 15,000 healthy physicians ≥50 years of age who were randomly assigned to receive 400 IU synthetic alpha-tocopherol (180 mg) every other day, 500 mg vitamin C daily, both vitamins, or placebo . During a mean follow-up period of 8 years, intake of vitamin E (and/or vitamin C) had no effect on the incidence of major cardiovascular events, myocardial infarction, stroke, or cardiovascular morality. Furthermore, use of vitamin E was associated with a significantly increased risk of hemorrhagic stroke." -ods. od .nih .gov/factsheets/VitaminE-HealthProfessional

"9 of 11 trials testing high-dosage vitamin E (≥400 IU/d) showed increased risk (risk difference > 0) for all-cause mortality in comparisons of vitamin E versus control. The pooled all-cause mortality risk difference in high-dosage vitamin E trials was 39 per 10 000 persons (95% CI, 3 to 74 per 10 000 persons; P = 0.035). For low-dosage vitamin E trials, the risk difference was −16 per 10 000 persons (CI, −41 to 10 per 10 000 persons; P > 0.2). A dose–response analysis showed a statistically significant relationship between vitamin E dosage and all-cause mortality, with increased risk of dosages greater than 150 IU/d." -

Meta-Analysis: High-Dosage Vitamin E Supplementation May Increase All-Cause Mortality

1Professor · ‎12-07-2014

@elated wrote:
@1Professor wrote:
@elated I was only responding to Essential 1,
which she said she was taking.
@1Professor The bottle states Essential 1, Nuoance Max. So maybe she left out the full name. It was new in April of 2025.

@elated Quite possible.

I was just worried that she thought she was getting 100, but the old Essential was only 10.

Thanks!!

[I'm convinced after reading more than 100 mg is not enough for a woman age 70.]

Often people aren't enthusiatic about supps where they can't see immediate noticable improvement.

I'm trying to get myself beyond that thinking.

JeanLouiseFinch · ‎10-03-2011

@poregirl wrote:
beware of extra vitamin E in any product. It contributes to all mortality. I avoid it like the plague.
"The most recent published clinical trial of vitamin E and men’s cardiovascular health included almost 15,000 healthy physicians ≥50 years of age who were randomly assigned to receive 400 IU synthetic alpha-tocopherol (180 mg) every other day, 500 mg vitamin C daily, both vitamins, or placebo . During a mean follow-up period of 8 years, intake of vitamin E (and/or vitamin C) had no effect on the incidence of major cardiovascular events, myocardial infarction, stroke, or cardiovascular morality. Furthermore, use of vitamin E was associated with a significantly increased risk of hemorrhagic stroke." -ods. od .nih .gov/factsheets/VitaminE-HealthProfessional

"9 of 11 trials testing high-dosage vitamin E (≥400 IU/d) showed increased risk (risk difference > 0) for all-cause mortality in comparisons of vitamin E versus control. The pooled all-cause mortality risk difference in high-dosage vitamin E trials was 39 per 10 000 persons (95% CI, 3 to 74 per 10 000 persons; P = 0.035). For low-dosage vitamin E trials, the risk difference was −16 per 10 000 persons (CI, −41 to 10 per 10 000 persons; P > 0.2). A dose–response analysis showed a statistically significant relationship between vitamin E dosage and all-cause mortality, with increased risk of dosages greater than 150 IU/d." -
Meta-Analysis: High-Dosage Vitamin E Supplementation May Increase All-Cause Mortality

The vitamin E TOCOTRIENOLS are a much better choice for heart, brain, and antioxidant support.

Shelbelle · ‎03-09-2010

My DH has been taking 400 Vit E Mixed Tocopherols daily for decades, he is now 75 no issues. In great health. Takes no meds either.

1Professor · ‎12-07-2014

@JeanLouiseFinch wrote:
@poregirl wrote:
beware of extra vitamin E in any product. It contributes to all mortality. I avoid it like the plague.
"The most recent published clinical trial of vitamin E and men’s cardiovascular health included almost 15,000 healthy physicians ≥50 years of age who were randomly assigned to receive 400 IU synthetic alpha-tocopherol (180 mg) every other day, 500 mg vitamin C daily, both vitamins, or placebo . During a mean follow-up period of 8 years, intake of vitamin E (and/or vitamin C) had no effect on the incidence of major cardiovascular events, myocardial infarction, stroke, or cardiovascular morality. Furthermore, use of vitamin E was associated with a significantly increased risk of hemorrhagic stroke." -ods. od .nih .gov/factsheets/VitaminE-HealthProfessional

"9 of 11 trials testing high-dosage vitamin E (≥400 IU/d) showed increased risk (risk difference > 0) for all-cause mortality in comparisons of vitamin E versus control. The pooled all-cause mortality risk difference in high-dosage vitamin E trials was 39 per 10 000 persons (95% CI, 3 to 74 per 10 000 persons; P = 0.035). For low-dosage vitamin E trials, the risk difference was −16 per 10 000 persons (CI, −41 to 10 per 10 000 persons; P > 0.2). A dose–response analysis showed a statistically significant relationship between vitamin E dosage and all-cause mortality, with increased risk of dosages greater than 150 IU/d." -
Meta-Analysis: High-Dosage Vitamin E Supplementation May Increase All-Cause Mortality
The vitamin E TOCOTRIENOLS are a much better choice for heart, brain, and antioxidant support.

@JeanLouiseFinch

Had time to research the tocotriendols,

new to me!

Wow.

So valuable.

Found the highest rated (on many sites) and just ordered.

(Amazon will deliver today!)

I am discontinuing my Lessman Essential 1.

Lots of vitamins that I am already getting in the new Lessman IMMUNE FACTORS (doesn't include E).

New is great, but eliminating duplicate supps is priceless.

Bella8888 · ‎08-25-2025

This discussion was a great use of social media!

Thank you everyone for your posts! I learned some new things.

🫶🏼

~ Be brave as a bear and have a heart like an ocean ~

JeanLouiseFinch · ‎10-03-2011

@1Professor wrote:
@JeanLouiseFinch wrote:
@poregirl wrote:
beware of extra vitamin E in any product. It contributes to all mortality. I avoid it like the plague.
"The most recent published clinical trial of vitamin E and men’s cardiovascular health included almost 15,000 healthy physicians ≥50 years of age who were randomly assigned to receive 400 IU synthetic alpha-tocopherol (180 mg) every other day, 500 mg vitamin C daily, both vitamins, or placebo . During a mean follow-up period of 8 years, intake of vitamin E (and/or vitamin C) had no effect on the incidence of major cardiovascular events, myocardial infarction, stroke, or cardiovascular morality. Furthermore, use of vitamin E was associated with a significantly increased risk of hemorrhagic stroke." -ods. od .nih .gov/factsheets/VitaminE-HealthProfessional

"9 of 11 trials testing high-dosage vitamin E (≥400 IU/d) showed increased risk (risk difference > 0) for all-cause mortality in comparisons of vitamin E versus control. The pooled all-cause mortality risk difference in high-dosage vitamin E trials was 39 per 10 000 persons (95% CI, 3 to 74 per 10 000 persons; P = 0.035). For low-dosage vitamin E trials, the risk difference was −16 per 10 000 persons (CI, −41 to 10 per 10 000 persons; P > 0.2). A dose–response analysis showed a statistically significant relationship between vitamin E dosage and all-cause mortality, with increased risk of dosages greater than 150 IU/d." -
Meta-Analysis: High-Dosage Vitamin E Supplementation May Increase All-Cause Mortality
The vitamin E TOCOTRIENOLS are a much better choice for heart, brain, and antioxidant support.

@JeanLouiseFinch

Had time to research the tocotriendols,
new to me!

Wow.

So valuable.

Found the highest rated (on many sites) and just ordered.
(Amazon will deliver today!)

I am discontinuing my Lessman Essential 1.
Lots of vitamins that I am already getting in the new Lessman IMMUNE FACTORS (doesn't include E).

New is great, but eliminating duplicate supps is priceless.

Eannatto, @1Professor ? That's what we have - the 125 mg.

1Professor · ‎12-07-2014

@JeanLouiseFinch

Yes!

Thats Me · ‎03-09-2010

@1Professor @Hi- mine is definitely 100mg, not 10. Unless he has changed formulations, I thought his essential 1 (when a TS, which is when I purchase it) was available with 100 or 200mg of CoQ10. I might up it to 200 next time I see it offered, but am ok with 100mg.