Wellness

[River Song]

I asked Mr. Google AI if ubiquinol supplements are converted to ubiquinone in the stomach.  The answer is yes, ubiquinol is converted to ubiquinone in the acidic stomach and alkaline small intestine.  It is converted to ubiquinol by the lymph system and enters the blood as ubiquinol.  The upshot being, it doesn't matter if the supplement is ubiquinone or ubiquinol.

What does matter is that the coQ10 is formulated with D-limonene and trans-geranylgeranis (from annatto seed) to enhance absorption.

Research on coQ10 is in the 100-300mg dosage, with benefits shown with the 100-200mg dosage.

Taking coQ10 in the evening can cause insomnia in some people.

[Shelbelle]

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@JeanLouiseFinch wrote:

I've read that an reasonable dosage is 200 mg. Unless specific health concerns require more.  We take 200 mg. of Qunol Kaneka Ubiquinol daily.  They come on 100mg. so we take two.  I've read that the Kaneka form is preferred.  

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Jean, from what I understand all Ubiquinol is from Kaneka. It think the brand is copyrighted or something legal like that. 

[Desertdi]

@River Song 

I flunked chemistry...Well, biology, too.    I fainted when they brought the frogs out....   (I got to take pre-Columbian history instead!)    So I'm assuming coQ10 is something I should consider taking???     di

[SilleeMee]

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@River Song wrote:

I asked Mr. Google AI if ubiquinol supplements are converted to ubiquinone in the stomach.  The answer is yes, ubiquinol is converted to ubiquinone in the acidic stomach and alkaline small intestine.  It is converted to ubiquinol by the lymph system and enters the blood as ubiquinol.  The upshot being, it doesn't matter if the supplement is ubiquinone or ubiquinol.

What does matter is that the coQ10 is formulated with D-limonene and trans-geranylgeranis (from annatto seed) to enhance absorption.

Research on coQ10 is in the 100-300mg dosage, with benefits shown with the 100-200mg dosage.

Taking coQ10 in the evening can cause insomnia in some people.

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@River Song 

It does matter. Ubiquinone's conversion to ubiquinol in older people declines and so it's better for older people to take ubiquinol instead to avoid the ubiquinone going to waste.

ETA-

With age there is a decline in enzyme activity needed for the conversion. Also with age there a fewer mitochondria in the body where much of the conversion occurs. Oxidative stress increases with age, too, and that also has a negative effect on the body's ability to convert the ubiquinone.

[River Song]

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@Desertdi wrote:

@River Song 

I flunked chemistry...Well, biology, too.    I fainted when they brought the frogs out....   (I got to take pre-Columbian history instead!)    So I'm assuming coQ10 is something I should consider taking???     di

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I actually liked chemistry, organic chemistry was much more interesting than inorganic chemistry.  Dissecting a preserved frog is nothing compared to looking for parasites in a freshly killed turtle or bird (yes I did, in my parasitology class).  But, I digress.

I don't take coQ10 supplements but after researching it, I may give it a try.  Seems to have a lot of benefits and not many downsides unless you are taking chemo drugs or blood thinners (drug interactions).  I'm not advocating it for other people since it's a personal decision based on what other medications someone is taking.

[Desertdi]

@River Song @1Professor 

I was no good at algebra, either.    Seems I don't comprehend "symbols".

Thanks for the recommendation!     I do take a multi every day...but I'm getting OLD and want to beat the odds.        di

[elated]

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@1Professor wrote:

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@Thats Me wrote:

I've taken Lessman's essential 1 with 100mg of CoQ10 for some years now. I do take a beta blocker, now a statin, and am 70. I don't want to get too crazy with supplements but have thought this was a good one along with the few others I take.

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@Thats Me 

I have a bottle of Lessman's Essential 1 and have take that for many years (now considering stopping as it has LOTS OF INGREDIENTS IN SMALL AMOUNTS.

ALERT to you: No, it does not give you 100 mg of coQ10.

The label reads: 10 mg.

Not enogh for any of us who hit 70.

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@1Professor  Lessman has a new Essential 1 called Nuonce Max. It states right on the label +100mg CoQ10.

[1Professor]

@elated   I was only responding to Essential 1,

which she said she was taking.

[elated]

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@1Professor wrote:

@elated   I was only responding to Essential 1,

which she said she was taking.

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@1Professor  The bottle states Essential 1, Nuoance Max. So maybe she left out the full name.  It was new in April of 2025.

[JeanLouiseFinch]

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@SilleeMee wrote:

If you're taking more than 100mg of ubiqunol each day, for instance 200mg, then split the dose in two and take half in the morning and the other half in the evening with food. The body cannot process high doses all at once so dividing the dose is better absorbed and processed while keeping sustained beneficial levels in the body throughout the day. Peak levels reach 6-8 hours after taking it and then decline to almost nothing after about a little over a day.

There's no established standard amount that the body absorbs at once. It will just get processed better if the dose is not a lot each time you take it. 

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I'm glad you mentioned this, @SilleeMee.  That's how we take ours.