No spoilers, but I hated the ending. I thought it was contrived and if you pay attention to the "clues" throughout the movie, you can figure out what's coming. I was also disappointed that Isabella Rossellini's role wasn't bigger. The acting overall was very good, but the storyline wasn't what I expected.
After watching it, I was reminded of a great movie from the past, "The Shoes of the Fisherman" with Anthony Quinn that dealt with the Vatican and Cold War politics based on an early 1960's book of the same name.