Community Chat

[pitdakota]

Marp, it really has broad implications, none the least of which is discovering how to block the enzyme that leads to the tangles. That in and of itself may have relevant implications for many other disorders.

[Marp2]

Pit,

Do you have a recommendation about where to follow the progress of this research without having to wait for media reporting? When/if they get to clinical trials on the medications is Centerwatch the best site to monitor for announcements?

[pitdakota]

I don't have access to the database that would have the "Nature" journal. That journal would not be in our medical library database that I can search from home.

However, I have access to all of the University library databases from work. So I will look up this article some time this week and see what I can find.

In the meantime, here is a basic website if you know the information to put in you can pull up info about various NIH grants

http://www.report.nih.gov/award/index.cfm

Do you subscribe to Pub-Med or any type of medical online database per chance?

[Marp2]

Pit, when I was working I did but eventually had to give up several subscriptions to medical and legal databases. They were no longer a justifiable expense.

I'll have to rely on what I can find online (UK is almost always a good parallel source) and your kindness.

With that I say thank you once again. Getting close to my bedtime so I will add goodnight and sleep well.

[pitdakota]

I will see what I can find out. Also, I have a meeting I think on Thursday?? with a good friend of mine that is an ARNP specializing in dementia employed in a research practice of neruologists. I will also ask her.

It is bedtime isn't it? Goodnight Marp!!

[Marp2]

Hi Pit,

Of course I went on a hunt for more information this morning and did pick up a couple of tidbits in different articles. One that particularly struck me is:

"And drugs that block beta amyloid prevent both plaques and tangles from forming, Dr. Tanzi and his colleagues reported.

“This provides strong support to the amyloid hypothesis and essentially cinches the serial link between amyloid and intracellular tangles,” Dr. Doraiswamy said. Now, he added, the challenge is to show that drugs that work in this system also help patients."

http://www.nytimes.com/2014/10/13/science/researchers-replicate-alzheimers-brain-cells-in-a-petri-di...

The following link is to the preview page of the Nature article: http://www.nature.com/nature/journal/vaop/ncurrent/full/nature13800.html#figures

[pitdakota]

Hi Marp. Just taking a quick break to let you know I spoke with a librarian today at lunch. That article was just published yesterday! So they don't have the Oct. print copy of Journal in yet and it will be a little while longer before the full online version will be available. However, she is going to send me an electronic copy when it is available.

Thanks for the other information!

[Marp2]

Thanks Pit. I haven't been this excited about research news in a long time.

[Marp2]

Hi Pit,

This is off topic but I have a question about removal of protective gear after treating an infectious patient.

Going by the graphic at http://apnews.myway.com/image/20141013/750132537722-AP_MAPS_20141013.html?date=20141013&docid=us-ebo... it appears that it is suggested removal from head to toe and I can see how easy it would be to self-infect following the procedures outlined. Especially after removing something confining it is pretty much instinct to subconsciously rub, scratch or otherwise touch the freed area.

Would it be practical for the caregiver to start with a disinfecting dip of their gloved hands for an appropriate amount of time before even starting the removal process and redipping as one proceeds from goggles/face shield down?

My thought is by disinfecting the gloves then following the other procedures two things would be accomplished. First, if the tie or fastener is not contaminated then using disinfected gloves would not transfer contaminants to the a new area. Second, if the gloves are the last to be removed and have been dipped in the disinfectant throughout the process not only would removal of the gloves be safer by removing them last the instinct to touch oneself would be significantly reduced.

It seems to me that removal of the gloves is the most likely place for self-infection to occur.

[Marp2]

N/M, I just found the answer to my next question.