Other than Retinol, nothing topical will change the deeper layers. The best prevention is a healthy diet, sunscreen, no smoking, and a solid skincare regimen early. I did not follow this advice, and now I am paying the price.
I have had a lot of different treatments that do work deeper, and yes, they do work, but it is not a one-and-done.
So far, I have done three Fraxels, three RF micro-needling, one Plasma Pen, and two Clear Lift facelifts. I have two more Clear Lifts scheduled over the next eight weeks and three RF micro-needling treatments planned in between the Clear Lifts. I also do Botox and fillers. I also do collegian in my coffee, take Collegan pills, and use bone broth in my cooking whenever possible.
I have high pain tolerance, and my esthetician works me over well, and while I see a small difference with each one, we are just starting to really see big payoffs.