Wellness

[Trinity11]

---

@cherry wrote:

HANGIN THERE @Trinity11 a cure might be just around the corner for you..for the rest of us as well

---

Thanks @cherry. I worry about my children and pray there is a cure in their lifetime. 

[cherry]

https://www.youtube.com/watch?v=eXft3cfed20

Try this link @Trinity11  I hope it works for you..It is a video about the new research the Dr is doing

[cherry]

This is exciting news for all diabetics, particularly type 1

https://www.youtube.com/watch?v=Ydhmash1N_A

[cherry]

Studies have found an association between insufficient sleep and the development of insulin resistance, one of the factors that cause type 2 diabetes, and now researchers have discovered a biological reason for this relationship, at least in men: an imbalance between their testosterone and cortisol hormones. The study results will be presented Sunday at ENDO 2018, the Endocrine Society's 100th annual meeting in Chicago, Ill.

"Our highly controlled sleep study showed that even one night of restricted sleep can cause insulin resistance and that we can dampen this effect by controlling levels of these two important hormones," said senior investigator Peter Y. Liu, M.B.B.S., Ph.D., a professor of medicine with the Los Angeles Biomedical (LA BioMed) Research Institute at Harbor-UCLA Medical Center, Torrance, Calif.

Insulin resistance occurs when the body does not properly use the hormone insulin. Testosterone is the main anabolic, or muscle-building, hormone, whereas cortisol -- often called the "stress hormone" -- helps catabolism, or breaking down energy and fat stores for use, Liu explained. Past research shows that sleep loss reduces a man's testosterone levels and increases cortisol levels.

Liu and his fellow researchers conducted five nights of sleep studies in 34 healthy men with an average age of 33. They controlled what the subjects ate and how much they slept, giving them 10 hours of sleep the first night and restricting them to four hours of sleep the remaining nights. The study received funding from the National Institutes of Health and the Clinical and Translational Research Center at LA BioMed.

In this "crossover" study, the men served as their own controls. In one series of sleep studies, they received three medications: ketoconazole, which switches off the body's production of testosterone and cortisol; testosterone gel; and oral hydrocortisone, a synthetic form of cortisol. The doses of testosterone and hydrocortisone were in the midrange of levels that the body normally produces, according to Liu. This arm of the study was called a dual "clamp" because it stopped the body's production of these two hormones and then gave them a fixed amount of the hormones, thus clamping levels in a normal hormonal balance, he said.

In another set of experiments, the men received inactive placebos that matched the medications. The order of when they received the clamp and the placebo was random, with a two-week interval between the study conditions. The morning after the first and last nights of each part of the study, all men took the oral glucose tolerance test, in which they gave blood samples while fasting and again after drinking a sugary drink. This test result allowed the researchers to calculate each man's insulin resistance using standard measures, including the Matsuda Index.

After sleep restriction, this index reportedly showed greater insulin resistance with both the clamp and the placebo. However, Liu said this increase was significantly dampened, or less severe, with the dual-clamp, demonstrating that testosterone and cortisol reduced the negative effects of sustained sleep restriction on insulin resistance.

"Maintaining hormonal balance could prevent metabolic ill health occurring in individuals who do not get enough sleep," he said. "Understanding these hormonal mechanisms could lead to new treatments or strategies to prevent insulin resistance due to insufficient sleep."

---

Story Source:

Materials provided by The Endocrine Society. Note: Content may be edited for style and length.

---

[cherry]

Claiming the lives of some 4,500 Jamaicans in 2006 alone, diabetes continues to plague the nation's people today.

Joining host Dr Sara Lawrence for episode three of Doctor's Appointment, Season Three, was diabetes expert Professor Michael Boyne, senior lecturer in endocrinology and metabolism at University of the West Indies, Mona, who debunked myths about the disease and offered sound advice for those affected by the illness.

Caused by a spike in blood-glucose levels, or excessive sugar in the blood, diabetes causes a person's body to have a delayed reaction to the hormone that regulates glucose, insulin. This disease is often hereditary, passed on through genes, brought on by lifestyle choices, such as diet, exercise or stress level, related to a person's age or developed as a side effect of other drugs/medication.

Diabetes has two main types:

- Type 1 - called insulin-dependence or youth-onset diabetes, and Type 2, called adult onset/non-insulin dependent diabetes. Type 1 often affects children and young people, causing their insulin levels to drop to as low as zero and forcing them to rely on taking insulin for survival. Research shows that this condition has no gender preference as it affects both men and women equally.

- Type 2 - more commonly found in adults where insulin levels are inconsistent and oftentimes stem from lifestyle choices. Afflicting the lives of women more than men, type two is greatly attributed to weight gain as well.

Prof Boyne explains that the average Jamaican woman is heavier or bigger in size than the average Jamaican man, and so is more at risk. He goes on to explain that if a woman is age 45 and gaining weight, she has an even higher chance of developing diabetes.

Another form, gestational diabetes, happens in the middle of a woman's pregnancy, causing her to have rising sugar levels. Prof Boyne assures that this form only affects the mother and not the child.

COMMON SYMPTOMS

Some common symptoms associated with diabetes include:

- Surging sugar levels

- Frequent urination

- Overeating coupled with rapid weight loss

- More infections

- Fatigue

- Having cuts that either take longer to or don't heal

Prof Boyne says in some diabetics, the symptoms take longer to develop, while others may not show symptoms at all. The condition also has unique manifestations, for instance, if a woman gives birth to a baby that weighs more than nine pounds, she may be showing signs of this disease.

Diabetes also has the tendency to lead to other maladies or health risks, such as:

- stroke

- heart attack

- the need for amputations

- kidney failure

- blindness.

Every part of the body is affected when someone has diabetes.

INHERITED TRAITS

The appointment continued with Lurlene Less, chairperson of the Diabetic Association of Jamaica and managing director of the Renal Unit, who joined Dr Lawrence on set to relate her own experience with the disease.

Less has been living with Type 1 diabetes for some 30 years, having been diagnosed in her early 20s. She explains that she developed diabetic neuropathy, which is nerve damage resulting in severe pains in arms and legs.

Less was never overweight, but her mother has Type 2 diabetes and so inherited the traits of the condition genetically.

But to conquer her illness, Less says management is key. To remain on top of her health she must take a number of precautions, including testing her blood sugar levels regularly, eating on time, taking medication, doing an A1 test twice a year, along with exercise and other physical activities. Yet, for Less these few steps mean a more fulfilled life.

One of her main concerns is the number of people who outrightly deny they have the condition and so refuse to seek treatment. This can lead to persons deteriorating more quickly and running the risk of developing other maladies in the process.

Less further explains that women who have diabetes have a higher probability of having a high-risk pregnancy.

TREATMENT OPTIONS

Prof Boyne joined the conversation with Less and Dr Lawrence to discuss treatment options for diabetics. Both guests suggest that persons living with the disease:

- Maintain a regular routine of monitoring their blood sugar levels

- Maintain healthy weight and diet

- Develop a manageable exercise regime

- Get enough sleep

- Reduce stress.

- Taking one of the more than 20 medications available to regulate insulin levels, or take insulin itself to maintain healthy blood-glucose levels.

The 6 p.m. Dr's Appointment Facebook live segment, season three's new feature, saw viewers talking directly with another of Jamaica's top consultants, Marshall Tulloch-Reid, Professor of Epidemiology and Endocrinology and Director of the Epidemiology Research Unit, Tropical Medicine Research Institute, The University of the West Indies.

PRACTICAL ADVICE

As in all the appointments, the experts gave viewers practical advice, such as:

- read widely

- visit the Diabetic Association of Jamaica, where diabetics can find a team of supportive and qualified persons versed in diabetic education and training.

- diabetics are encouraged to learn the ABCs of diabetes, namely: A1c testing, blood pressure checking and cholesterol control.

[cherry]

My Dr(endocrine) mentioned to me, that lack of a good nights sleep, will give you a high morning BS reading

I have had stomach issues for over a year, that are slowly getting better, but  my morning blood sugar readings were always a lot higher, than prior to my digestive issues

It has been slowy coming down, since I am not wakened every 2 hrs , and need to take meds to calm it down, so I can go back to sleep

Today, my reading was 110 ,the lowest it has been in a year. I hope I can keep it at this level, I was only wakened once last night..so many things, that have nothing to do with food, can affect us

[cherry]

Although green tea has been getting most of the attention lately for its myriad health benefits, accumulating research shows that black tea offers advantages, too. The latest revelation: black tea’s ability to blunt increases in blood sugar. 1

A new study has found that black tea significantly reduces rises in blood glucose levels among both healthy and pre-diabetic adults, in this case after consuming a sugary drink. 1

“We demonstrated that black tea reduced incremental blood glucose after sucrose consumption at 60, 90 and 120 minutes compared with placebo,” wrote the authors of the study, which appears in the Asia Pacific Journal of Clinical Nutrition. 1

“The data confirm that polyphenols lower glycemic response and may be responsible for the lower rates of diabetes observed with tea and coffee consumption,” said Peter Clifton, M.D., PhD., professor of nutrition at the University of South Australia in Adelaide, who recently conducted a review of the role of dietary polyphenols (in tea, cinnamon, coffee, chocolate, pomegranate, red wine and olive oil, among others) in regulating glucose homeostasis and insulin sensitivity, published in Nutrients. 2, 3 

The Polyphenol Power of Tea

Indeed, the major bioactive compounds in black tea are polyphenols—naturally occurring antioxidants abundant in plant foods (and drinks) that are said to promote health and protect against a range of diseases. 4

Black, green and oolong teas are all made from the plant Camellia Sinensis. Green tea, which is minimally oxidized, contains simple flavonoids called catechins. During the process of making black tea, which is more fully oxidized, the catechins convert to complex flavonoids known as theaflavins and thearubigens, and research has shown that theaflavins and thearubigens maintain substantial anti-oxidant, anti-inflammatory, anti-cancer and anti-hypertensive properties. 5

“The new study confirms the findings of a number of biological, physiological, clinical, epidemiological and ecological studies suggesting a positive effect of black tea consumption on diabetes prevention and clinical diabetes,” said Ariel Beresniak, M.D., PhD., chief executive officer of Data Mining International in Geneva and lead author of a large global study on black tea and health published in the British Medical Journal. 5,6

That study, which involved data from 50 countries around the world, found that countries with the highest levels of black tea consumption—Ireland followed by the United Kingdom, Turkey and Russia—were associated with the lowest incidence of type 2 diabetes. The U.S. ranked close to the bottom of the list of black-tea drinking countries. 5

Proving Cause and Effect 

Still, the new study doesn’t prove cause and effect, Dr. Beresniak said, adding that more causality research needs to be done on the glucose-control benefits of black tea. 6

While black tea extracts have been shown in laboratory experiments to block carbohydrate absorption and to suppress postprandial blood glucose in animal studies, the authors of the latest report said they undertook their study because of the relative dearth of clinical research on the effects of black tea on postprandial glycemic control in humans. 1

The authors also noted that keeping blood sugar in check after meals is a critical but simple way to help prevent diabetes, and that black tea, regarded as a functional food, may be useful to that end. 1

Tea, after water, is the most widely consumed beverage in the world. About 78% of the tea produced worldwide is black and is used primarily in Europe and North America; about 20% is green and is consumed mostly in Asian countries; and about 2% is oolong, which undergoes a level of oxidation somewhere in between green and black teas and is favored in China and Taiwan. 7

As of 2015, 415 million people in the world—one of 11 adults—have diabetes, according to the Brussels-based International Diabetes Federation. By 2040, that number is expected to climb to 642 million. An estimated 318 million worldwide have impaired glucose tolerance, or prediabetes. 8

The U.S. leads the developed world in diabetes, with more than 29 million cases among adults, according to the Centers for Disease Control and Prevention. About 86 million adults in the country—more than one-third of the population—have pre-diabetes, a serious health condition that increases the risk of developing type 2 diabetes as well as other chronic diseases. The vast majority of those with pre-diabetes (90%) don’t know they have it. 9

[cherry]

With commentary by lead study author Laurent Azoulay, PhD, associate professor, centre for clinical epidemiology, at Jewish General Hospital, in Montreal.

For years, a drug used to treat diabetes has been linked to an increased risk of bladder cancer, but the research to support a strong association had been lacking.  Now a new study reveals strong evidence that pioglitazone does in fact increase the risk of bladder cancer, and that the increased risk can occur as quickly as about 22 months on the drug. 

Warnings from the U.S. Food and Drug Administration about the risk of bladder cancer from pioglitazone were issued in 2011. The FDA warned that the use of the medication pioglitazone (Actos, Oseni, Duetact) for more than one year may be associated with an increased risk of bladder cancer, and advised those with bladder cancer not to take it. But the agency stopped short of recommending that others avoid it, even those with increased risk of the cancer. The drug remains on the market, and some of the drugs containing pioglitazone have been approved since the 2011 warning. 

Researchers from Canada set out to conduct a study that avoided some of the weaknesses of past research, such as past use of medications or existing bladder cancer in subjects. They conducted a large, population-based study of more than 145,800 patients from the UK, and compared the use of pioglitazone with rosiglitazone (Avandia), which is in the same class of drugs called thiazolidinediones, as well as other diabetes drugs. 

The study, published in The BMJ, included patients who were given diabetes drugs for the first time between 2000 (the year pioglitazone and rosiglitazone entered the UK market) and 2013. Patients were followed by a mean of 4.7 years. The authors excluded all patients with a diagnosis of bladder cancer and created a one-year lag time to make sure that patients did not have bladder cancer that hadn’t yet been diagnosed.

Compared with taking no thiazolidinedione, the use of pioglitazone was associated with a 63 percent increased risk of bladder cancer. The risk increased with higher doses and length of time on the drug. In contrast, the use of rosiglitazone was not associated with an increased risk of bladder cancer in any analysis.

When pioglitazone was compared to rosiglitazone head to head, pioglitazone was associated with a 48 percent increased risk of bladder cancer compared to rosiglitazone.

“We believe that our findings are quite compelling,” says Laurent Azoulay, PhD, associate professor, centre for clinical epidemiology, at Jewish General Hospital, in Montreal. “Given their similarities, any bias observed with pioglitazone would have also been expected with rosiglitazone. The fact that rosiglitazone was not associated with bladder cancer in any of our analyses provides some reassurance on the pioglitazone findings,” he says.

There’s a slight difference between the two drugs and the receptors they activate. The type that pioglitazone activates has been shown to increase the expression of carcinogenic biomarkers in the bladder. But the authors stress that additional studies are needed to better understand the mechanisms.

The authors stress that, in absolute terms, the risk of bladder cancer remains low. According to the American Cancer Society, men have a 1 in 26 chance of developing bladder cancer, while women have a 1 in 88 chance.

Azoulay suggests that doctors and patients should be aware of this association when weighing the overall risks and benefits of this therapy.  “Certainly patients with bladder cancer or other bladder conditions should not use the drug, but ultimately the decision to prescribe this drug will lie with the treating physician,” says Azoulay.

[cherry]

apid swings in blood sugar levels caused by eating too much sugar or too little sugar can sometimes cause headaches.

Headaches can range from annoying to debilitating, so understanding what triggers a headache can significantly improve a person's quality of life.

For some people who experience migraines, sugary foods may be a trigger.

Can sugar give you a headache?

Headaches may be caused by too much or too little sugar.

Both too much and too little sugar can cause a headache. Consuming too much sugar can cause high blood sugar levels (hyperglycemia). Consuming too little sugar can cause low blood sugar levels (hypoglycemia).

Low blood sugar can cause a range of symptoms, including headaches and muscle pain. People who take insulin have a higher risk of having low blood sugar levels.

People who consume too much sugar, who are insulin resistant, or who have diabetes are more vulnerable to high blood sugar. If a person consumes a lot of sugar at once, then does not have any more in the period that follows, they may experience a sugar crash, which can cause a headache.

Sugar may trigger hormonal changes, particularly in the hormones epinephrine and norepinephrine. These hormonal shifts change the way blood vessels in the brain behave, potentially triggering a headache.

It is not the sugar itself that causes a person to develop a sugar headache. What triggers a headache is a rapid shift in blood sugar, due either to consuming too much sugar or not eating enough. These changes in blood sugar can induce a headache and other symptoms, which some people call a sugar hangover.

https://www.medicalnewstoday.com/articles/5089.php

Related conditions

Some medical conditions make people more prone to sugar-related headaches, including:

Diabetes

Managing blood sugar naturally is not possible for people with diabetes, so they may be more prone to sugar-related headaches.

People with diabetes are not able to manage their blood sugar levels naturally. When their blood sugar gets too high or too low, they may experience headaches.

More blood sugar fluctuations typically mean more headaches, so people with diabetes who struggle to manage their condition or do not take medication as prescribed may be more vulnerable to diabetes-related headaches.

Unmanaged diabetes can damage the blood vessels, which may change blood circulation to the brain and increase the risk of headaches.

Blood vessel damage can also increase the risk of heart and brain conditions that cause headaches. A sudden, intense headache could be due to a stroke, blood clot, or an aneurysm.

Some people with diabetes develop a condition called diabetic ketoacidosis when the body uses fat instead of sugar for energy. People with diabetic ketoacidosis sometimes experience intense headaches, in addition to swelling, confusion, or loss of consciousness.

Migraine

Changes in diet and blood sugar fluctuations may trigger migraines in some people who regularly have them.

Every individual has different triggers, so it is crucial for a person to keep a record of when their migraines occur to determine whether sugar is a trigger.

A 2006 study linked the sweetener sucralose that is found in Splenda to migraines, meaning that even sugar substitutes may play a role in causing sugar headaches.

[Q4u]

Incredibly valuable information, thank you so much for sharig!