Wellness

[bluejeansluvr]

I am so sorry about your daughter. Yes I completely understand about the ignore thing-- it's sad isn't it.

I wish your daughter the best. Please keep us updated about her. I hope she finds treatment that will help her.

[Mindy D]

On 3/3/2015 ibb38 said:

On 3/3/2015 Mindy D said: Borrelia burgdorferi, the causative agent of Lyme disease, utilizes manganese (Mn) for its various metabolic needs. We hypothesized that blocking Mn transporter could be a possible approach to inhibit metabolic activity of this pathogen and eliminate the infection. We used a combination of in silico protein structure prediction together with molecular docking to target the Borrelia metal transporter A (BmtA), a single known Mn transporter in Borrelia and screened libraries of FDA approved compounds that could potentially bind to the predicted BmtA structure with high affinity. Tricyclic antihistamines such as loratadine, desloratadine, and 3-hydroxydesloratadine as well as yohimbine and tadalafil demonstrated a tight binding to the in silico folded BmtA transporter. We, then, tested borreliacidal activity and dose response of the shortlisted compounds from this screen using a series of in vitro assays. Amongst the probed compounds, desloratadine exhibited potent borreliacidal activity in vitro at and above 78 µg/mL (250 µM). Borrelia treated with lethal doses of desloratadine exhibited a significant loss of intracellular Mn specifically and a severe structural damage to the bacterial cell wall. Our results support the possibility of developing a novel, targeted therapy to treat Lyme disease by targeting specific metabolic needs of Borrelia.

'hypothesized', 'theorized', 'possibility'- all very tentative without clinicals. Claritin has it's own set of issues for some people as well.

IBB38, the post is the actual abstract from the real study. Abstracts are summaries of studies and must include key parts of scientific investigations. These investigations include what is called a problem statement, in other words, a question the investigators want to answer. The study should include a possible answer to the question, based on previous related studies and the body of information in the area. This part of the investigation is called the hypothesis. Then the study should include specific procedures used, including exact materials and methods. The study should include results which are put into both word form and chart form-such as graphs, when appropriate. There should also be a conclusion which states whether the findings support or do not support the hypothesis. The abstract would also be included to provide other investigators the opportunity to quickly preview the investigation and findings. The abstract should summarize the parts of the investigation I have noted. More than one trial should be attempted and included in the results. This study investigated the whether Claritan/desloratidine and four other substances, could bind with a second substance and block manganese from the cells of the organism that causes Lyme. Manganese is necessary for metabolism in Borellia, the bacteria tat causes Lyme. . It was found that desloratine could bind with the second substance and block manganese in the bacteria that causes Lyme. It was also found that there was severe structural damage to the Borellia cells. This finding lead to the support for the possibility of using this strategy as a possible way to treat Lyme in the future.

[Ibby114]

The best way to find a lyme specialist is through a teaching hospital- much of the mis information would be averted. These reliable websites are also a great resource:

cdc.gov/ncidod/dvbid/lyme;

niaid.nih.gov/topics/lymedisease/pages/lymedisease;

fda.gov/forconsumers/consumerupdates/ucm

[LilacTree]

On 3/4/2015 imaclotheshog said:

I am so sorry about your daughter. Yes I completely understand about the ignore thing-- it's sad isn't it.

I wish your daughter the best. Please keep us updated about her. I hope she finds treatment that will help her.

Thank you so much.

[Justina rae]

An interesting and hopeful article. Thank you for sharing Ford. I'm sorry about your daughter. I contracted Lyme about 20 years ago but it was promptly treated and I don't seem to have any after effects.

From the article...being that B. burgdorferi requires manganese for its metabolic processes...I wonder how reducing from one's diet at least short-term in the foods that are highest in manganese might affect or retard reproduction of the bacterium???

[LilacTree]

On 3/8/2015 Justina rae said:

An interesting and hopeful article. Thank you for sharing Ford. I'm sorry about your daughter. I contracted Lyme about 20 years ago but it was promptly treated and I don't seem to have any after effects.

From the article...being that B. burgdorferi requires manganese for its metabolic processes...I wonder how reducing from one's diet at least short-term in the foods that are highest in manganese might affect or retard reproduction of the bacterium???

My daughter would know that, but I don't. I can't keep up with all the terms she uses. She eats a special diet . . . I guess I will find out more about that after we move in together. She tells me what it is, but I can never remember it because I've never heard of these foods before.

[Gooday]

I have a serious question.

I will be returning to Illinois next week. We have a high second floor condo that sits about 100 feet away from a county forest preserve. We have a variety of animals around the back of our complex as there is a county easement with lots of grass. A neighbor has had a bird feeder for water and grain to which the deer flock in droves! (Sorry but I believe in survival of the fittest and culling of the herds when necessary). I have lived there since 1999 and have never had a problem with ticks, nor have any of my neighbors.

My question is there a preventative spray available or how do you know if you've been bitten. I would think as close as we are, ticks would be all over the place.

[LilacTree]

On 3/8/2015 Justina rae said:

An interesting and hopeful article. Thank you for sharing Ford. I'm sorry about your daughter. I contracted Lyme about 20 years ago but it was promptly treated and I don't seem to have any after effects.

From the article...being that B. burgdorferi requires manganese for its metabolic processes...I wonder how reducing from one's diet at least short-term in the foods that are highest in manganese might affect or retard reproduction of the bacterium???

"Promptly treated" is the key . . . within three weeks to a month. And even then, it remains inside you forever. The key is to keep healthy and never do anything to compromise your immune system.

My daughter was treated with antibiotics 30 years ago, and she was not bitten recently. It just raised its ugly head because she has been immensely stressed for so long and her immune system just gave up.

I'm afraid I lost a friend recently because she was treated for Lyme right away and feels as many do, that there is no such thing as "chronic Lyme." I sent her a few articles and she got very angry, so I apologized and did not send them to her anymore. However, it has been some time since I've heard from her. I will attempt to contact her after we move.

[depglass]

You will usually know if you get bitten. They will leave a giant red itchy raised mark and possibly be burrowed into the skin. We have ticks like crazy in our area and I had three bites last year, just from minimal amounts of gardening. I routinely get a lyme test at the end of each summer I've had a bite. My pharmacist friend said don't rush in for a test, wait a few weeks. There is a product called Permethrin that we bought from our local state extension service. It is for clothing, gear, and tents, NOT for skin. Not for casual use if you just have deer near your condo. Notice I said "usually," I've heard of people with no marks whatsoever that have tested positive.

[bullyluv]

On 3/8/2015 Gooday said:

I have a serious question.

I will be returning to Illinois next week. We have a high second floor condo that sits about 100 feet away from a county forest preserve. We have a variety of animals around the back of our complex as there is a county easement with lots of grass. A neighbor has had a bird feeder for water and grain to which the deer flock in droves! (Sorry but I believe in survival of the fittest and culling of the herds when necessary). I have lived there since 1999 and have never had a problem with ticks, nor have any of my neighbors.

My question is there a preventative spray available or how do you know if you've been bitten. I would think as close as we are, ticks would be all over the place.

You can always spray a bit on your balcony. It will help, a bit. Birds can carry ticks and then drop off the bird into sprayed yards however. Your best bet it to avoid long grasses, and plants like Hostas and lilies. Ticks will hang off the grasses and leaves and then hitch a ride onto you or pets. Since my neice has Lyme disease, my family is pretty paranoid about it. We don't go for walks in the woods any more at all, no forest preserves. We walk on sidewalks, I am very careful about brushing up against plants if any kind. Do ticks checks often if you have been outside. the spring is when they are most active I have found. People will think you are crazy, so what! I am willing to take serious precautions. I have a dog I only allow to walk on the sidewalk, if the grass is fresh trimmed he can go on that, no long grasses! I also do a check on him after every time he is outside. Towards the summer and end of summer I don't worry as much but I have pulled three ticks off of him, and I am very careful about where he walks! These horrible ticks really can hide! Be very careful always! And yes be paranoid!