Yes, I've used it. A couple of years ago I had a splinter deep in my heel. I couldn't remove it, so I went to the doctor. He used a scalpel and couldn't find it so we figured maybe I was just having pain from the injury. After about a week, I could still feel that sticking sensation when I walked, so I started using the Prid. About 4 or 5 days later I noticed a round hole in my heel when I was changing the bandage. I gave it a gentle squeeze, and a huge thick splinter slid right out. More like a piece of wood than just a splinter.
I know that splinters can come out on their own, but sometimes they don't. Just by the way this one came sliding out, I believe the Prid helped. It doesn't actually draw anything out, but softens the skin enough to allow whatever is under it to come out. It has lots of 5-star reviews, and I'll always keep a tin on hand.