Wellness

[willdob3]

How much COQ10 do you (those of you who take Andrew's) take? Do you see noticeable improvements in how you feel when taking it?

I've been researching on COQ10 & I am going to double my dose; as of today, I am going to take it (200mg) twice a day.

I've never had noticeable improvements from taking it & I hope taking it twice per day changes that. Some of what I read suggests we should feel things like more energy (just one example) when we are getting the correct dose for us - so dosage will vary depending on the person.

This is a good time to do increase because I got the largest bottle last October - 600 capsules. I know I only got that size because the next smaller size was only 300 capsules, not enough to go a full year. I've got tons left!

I'll get the largest container (assuming same size containers are offered) this coming October, too. I figure I will have plenty to get through the next year taking 2 per day. Once I get the new TS COQ10, I'll take the new one with added D3 in the morning & take the one w/o it in the evening.

[VaBelle35]

I take 200mg daily.  I researched the dosing and how long the studies were for and the longest study I found was 2.5 years at about 200mg for heart disease.

You start getting into liver enzyme issues long term at high doses.

[willdob3]

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@VaBelle35 wrote:

I take 200mg daily.  I researched the dosing and how long the studies were for and the longest study I found was 2.5 years at about 200mg for heart disease.

You start getting into liver enzyme issues long term at high doses.

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I must have missed that about liver enzymes. I have not read anything about problems with high doses other than extreme ones possibly causing gastrointestinal issues. Suggestions were that there are no negative side effects & dosages I read about went as high as 3,600mg - for specific health problems.

[VaBelle35]

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@willdob3 wrote:

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@VaBelle35 wrote:

I take 200mg daily.  I researched the dosing and how long the studies were for and the longest study I found was 2.5 years at about 200mg for heart disease.

You start getting into liver enzyme issues long term at high doses.

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I must have missed that about liver enzymes. I have not read anything about problems with high doses other than extreme ones possibly causing gastrointestinal issues. Suggestions were that there are no negative side effects & dosages I read about went as high as 3,600mg - for specific health problems.

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Correct.  There are 1000s of studies for various treatments and the doses go as high as the 10ks, but they are only for periods of time like 8 weeks, 12 weeks, 6 months.  When reviewing the list of studies on Mayo Clinic, you will see the lengths of the studies in a snapshot form.

Since my focus is cardiovascular disease due to family history, I looked at the CV studies on pubmed.gov and there is only one at the 2.5 year mark that I found when I first started looking at CoQ10 about 2 years ago (maybe a little more).

[VaBelle35]

Just looking quickly at 2016 studies, a Swedish study published in July 2016 shows 200mg for 5.2 years.

The study was on selenium, but they gave them 200mg of COQ10 along with it and tracked mortality in elderly due to CV disease.

[willdob3]

@VaBelle35 - I just located info about COQ10 & liver enzymes. What I read said that problems are rare. I also read a study that showed COQ10 can improve the condition if someone has NAFLD (I don't but interesting).

I haven't seen anything that would cause concern for me though it is good to be aware of possible issues just in case something were to show up in labs - good or bad. 

[VaBelle35]

Exactly.

I just like to know what I'm getting into and what they've studied and for how long before I make my decision on how much to take.  I feel great on 200mg, but I also eat Primal and so that probably has more to do with it than the CoQ10.

[HappyDaze]

Please do research on vitamin D3 supplementation. There are many studies coming out now showing that it can actually contribute to heart disease, etc. especially at higher levels. It is not something people should just add a bunch of it to their supplementation without talking to their doctors, especially if you have certain conditions and genetic pre-disposition to things ilke heart disease.

[willdob3]

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@HappyDaze wrote:

Please do research on vitamin D3 supplementation. There are many studies coming out now showing that it can actually contribute to heart disease, etc. especially at higher levels. It is not something people should just add a bunch of it to their supplementation without talking to their doctors, especially if you have certain conditions and genetic pre-disposition to things ilke heart disease.

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Yes, people should know if they actually need to supplement this (and any other vitamin) before deciding to take it. 

[VaBelle35]

Agreed!  People hear on the news that people need to take Vitamin D, so they take it and then there's the whole "more is better" attitude.

My mother's husband practically killed himself with Vitamin C.  He was taking obnoxious amounts to the point where he was getting nose bleeds constantly.

More is not better.