topic Re: TruNiagen??? in Wellness

TruNiagen???

Starpolisher — Sat, 31 Dec 2022 12:59:26 GMT

Has anyone tried this anti aging supplement(vitamin B3 known as nicotinamide riboside, ShopHQ) Suppose to increase energy levels(rebuilds energy at a cellular level), help with sleep and overall wellness. Would like opinions please.

Re: TruNiagen???

pdxlalesley — Sat, 31 Dec 2022 14:32:49 GMT

@Starpolisher Yes, I have been taking one capsule daily for a bit over 8 weeks. Just a few days ago realised that I am now sleeping straight through the night 5.5 hours, and my usual was 3 hrs, and that was a struggle. Now I fold up the tent at 7 or 8 at night, and when I wake up I actually want to do things around the house.

I do have more energy, doing normal tasks, cooking, etc and my mood has lifted. I have not been doing anything or taking anything new except for the TruGEN,

I am not a believer in miracles re potions and supplements, but I do think that the TG has "kicked in" and I'm reaping the benefits.

Re: TruNiagen???

Shelbelle — Sat, 31 Dec 2022 14:52:17 GMT

FYI, you can find this same product for a lot less, lots of brands out there, jus check to see that ingredients are the same as on SHQ. You can also find Tru Niagen on ebay for less.

Re: TruNiagen???

Starpolisher — Sat, 31 Dec 2022 18:59:17 GMT

@pdxlalesley

Thank you! I ordered it. I would love to be able to sleep throughout the night! @Shelbelle Thank you also! I will try it through ShopHQ first. If I like it then I will look at other places.

Happy New Year to you both!🥂🍾🎉

Re: TruNiagen???

JeanLouiseFinch — Sun, 01 Jan 2023 16:35:57 GMT

I don't use this particular one, but do use an NAD supplement. I can't say I notice anything, but continue putting faith in what they say it does.

Re: TruNiagen???

Mimi NY — Sun, 01 Jan 2023 19:22:08 GMT

@pdxlalesley wrote:
@Starpolisher Yes, I have been taking one capsule daily for a bit over 8 weeks. Just a few days ago realised that I am now sleeping straight through the night 5.5 hours, and my usual was 3 hrs, and that was a struggle. Now I fold up the tent at 7 or 8 at night, and when I wake up I actually want to do things around the house.

I do have more energy, doing normal tasks, cooking, etc and my mood has lifted. I have not been doing anything or taking anything new except for the TruGEN,

I am not a believer in miracles re potions and supplements, but I do think that the TG has "kicked in" and I'm reaping the benefits.

Thank you for your review have seen this brand on Shop HQ and was hoping I would find someone on this forum that has tried it, I would want it for sleep as I got older I can't get a full night of sleep.Seems like it is working for you. Been a Customer of Andrew

Lessman supplements for many years and now wondering why he hasn't developed something with Niagen, sounds like it might be a miracle for us who need help with getting a good night of sleep.

Re: TruNiagen???

kate2357 — Sun, 01 Jan 2023 21:19:15 GMT

Yes, sleeping thru the night would be nice. I have tried several things, but not this product.

Currently trying Winged Wellness cbd sleep gummies- hemp and not having consistent results. I can't double the qty I take because if I take more than 3 mg of melatonin I get horrible dreams.

CAREFUL with this supplement .....

GingerHead — Mon, 02 Jan 2023 04:00:03 GMT

....recent studies have found that B3 supplementation can potentially increase your risk of various cancers. Please research before supplementing.

https://showme.missouri.edu/2022/insight-to-popular-supplements-potential-role-in-cancer-progression/

https://pubmed.ncbi.nlm.nih.gov/14690785/

Re: CAREFUL with this supplement .....

cantdrive55 — Mon, 02 Jan 2023 17:17:53 GMT

Thank you @GingerHead, the Mizzou article was a fascinating read.

Re: CAREFUL with this supplement .....

Shelbelle — Mon, 02 Jan 2023 17:59:57 GMT

I wonder if Danny Seo and SHQ execs have seen this article.

Re: TruNiagen???

imaboomer — Tue, 03 Jan 2023 20:33:57 GMT

Another report:

Elysium is aware of this study, and we have reviewed it with our scientific team—the research was poorly conducted and the articles covering it are spreading misinformation. We have found numerous additional issues that support our position that neither this article nor the related media coverage is credible (more details below).

One of the authors has even publicly stated, "The title of the news article 'Popular Dietary Supplement Causes Cancer Risk and Brain Metastasis' is clickbait material and totally inaccurate from a scientific standpoint. The experiment in [the article] does not allow for this conclusion."

Elysium has been in contact with the journal, which is investigating and has already issued an "expression of concern" about the article noting that “they are seriously taking action following the publisher's protocol with the engagement of the publisher's Ethics team.” Elysium has also reached out to the university, which has issued several corrections to its press release and is conducting its own investigation.

1. The first experiment on the FVB mice with or without NR in the diet did not come close to reaching statistical significance for tumor formation. Any scientist would consider this data as grossly misinterpreted. Based on this alone, the paper should not have been published.

2. In the second experiment, the mice were genetically engineered to have no thymus, without which they cannot make T cells. This is a terrible design to assess tumor growth, because the mice totally lack an immune system. Thus, it is not a model for human cancer at all. It also employs injection of tumor cells followed by scoring of where tumors form. Since there is no primary tumor, brain tumors do not represent metastasis, as the authors claim, but simple homing. It's made worse by the fact that the mice were inoculated with an already metastatic cancer cell line. In sum, conclusions about metastasis cannot be drawn from this. In addition, the experiment also only barely reached significance - given all of this, it does not come close to passing muster.

3. The injected dose of NR in the second experiment was unnecessarily large, equivalent to nearly 400X the standard daily recommended dose of NR in humans, which is 250mg. This was administered daily. Human NR supplements only raise NAD+ back to youthful levels, a modest increase within the normal range of human biology. This standard NR dose has not been shown to cause or increase the risk of cancer. We assume that this incredibly high dose was necessary for the function of the AzNR probe, and have appealed to the journal to clarify this point. To that end, we have also reiterated that the probe should be the focus of the paper and the immensity of the dose should be clearly communicated.

4. Finally, no dietary supplement that Elysium is aware of contains AzNR, yet all the mice that were administered NR in the second experiment also received AzNR. The inclusion of AzNR makes it impossible to conclude what NR alone is or is not doing.

Including this study, we know of no credible evidence that NR supplementation affects cancer or metastasis or has any material impact on adjuvant chemo or radiotherapy. The novelty of the paper relates to the new AzNR probe, and the two mouse experiments are without merit. Individuals receiving treatment for cancer should consult with their physician before starting or stopping use of Basis. Research and further information on Basis is housed on our website here, should you want to share this directly with your physician.

Unlike the unnatural scenario in this study, Basis has been studied in at-risk populations. In 2019, Elysium even announced the acceptance of an Investigational New Drug ("IND") application by the Food and Drug Administration (FDA) to evaluate the efficacy of Basis for the prevention of acute kidney injury (AKI) in surgical cardiac patients, a unique achievement for a dietary supplement. The IND acceptance enabled the initiation of a Phase II, randomized, double-blinded, placebo-controlled clinical trial to evaluate the efficacy of Basis for kidney protection against AKI in patients treated by complex aortic aneurysm repair and aortic arch reconstruction, which began at Mayo Clinic in 2020 and is estimated to complete in 2024.

Re: TruNiagen???

GingerHead — Wed, 04 Jan 2023 03:20:37 GMT

@imaboomer wrote:
Another report:

Elysium is aware of this study, and we have reviewed it with our scientific team—the research wa
s poorly conducted and the articles covering it are spreading misinformation. We have found numerous additional issues that support our position that neither this article nor the related media coverage is credible (more details below).

One of the authors has even publicly stated, "The title of the news article 'Popular Dietary Supplement Causes Cancer Risk and Brain Metastasis' is clickbait material and totally inaccurate from a scientific standpoint. The experiment in [the article] does not allow for this conclusion."

Elysium has been in contact with the journal, which is investigating and has already issued an "expression of concern" about the article noting that “they are seriously taking action following the publisher's protocol with the engagement of the publisher's Ethics team.” Elysium has also reached out to the university, which has issued several corrections to its press release and is conducting its own investigation.

1. The first experiment on the FVB mice with or without NR in the diet did not come close to reaching statistical significance for tumor formation. Any scientist would consider this data as grossly misinterpreted. Based on this alone, the paper should not have been published.

2. In the second experiment, the mice were genetically engineered to have no thymus, without which they cannot make T cells. This is a terrible design to assess tumor growth, because the mice totally lack an immune system. Thus, it is not a model for human cancer at all. It also employs injection of tumor cells followed by scoring of where tumors form. Since there is no primary tumor, brain tumors do not represent metastasis, as the authors claim, but simple homing. It's made worse by the fact that the mice were inoculated with an already metastatic cancer cell line. In sum, conclusions about metastasis cannot be drawn from this. In addition, the experiment also only barely reached significance - given all of this, it does not come close to passing muster.

3. The injected dose of NR in the second experiment was unnecessarily large, equivalent to nearly 400X the standard daily recommended dose of NR in humans, which is 250mg. This was administered daily. Human NR supplements only raise NAD+ back to youthful levels, a modest increase within the normal range of human biology. This standard NR dose has not been shown to cause or increase the risk of cancer. We assume that this incredibly high dose was necessary for the function of the AzNR probe, and have appealed to the journal to clarify this point. To that end, we have also reiterated that the probe should be the focus of the paper and the immensity of the dose should be clearly communicated.

4. Finally, no dietary supplement that Elysium is aware of contains AzNR, yet all the mice that were administered NR in the second experiment also received AzNR. The inclusion of AzNR makes it impossible to conclude what NR alone is or is not doing.

Including this study, we know of no credible evidence that NR supplementation affects cancer or metastasis or has any material impact on adjuvant chemo or radiotherapy. The novelty of the paper relates to the new AzNR probe, and the two mouse experiments are without merit. Individuals receiving treatment for cancer should consult with their physician before starting or stopping use of Basis. Research and further information on Basis is housed on our website here, should you want to share this directly with your physician.

Unlike the unnatural scenario in this study, Basis has been studied in at-risk populations. In 2019, Elysium even announced the acceptance of an Investigational New Drug ("IND") application by the Food and Drug Administration (FDA) to evaluate the efficacy of Basis for the prevention of acute kidney injury (AKI) in surgical cardiac patients, a unique achievement for a dietary supplement. The IND acceptance enabled the initiation of a Phase II, randomized, double-blinded, placebo-controlled clinical trial to evaluate the efficacy of Basis for kidney protection against AKI in patients treated by complex aortic aneurysm repair and aortic arch reconstruction, which began at Mayo Clinic in 2020 and is estimated to complete in 2024.

I don't know if I'd necessarily trust what Elysium says on the subject as they sell the supplement in question.

This isn't just clickbait. It's a known fact that cancer cells have high metabolic needs, including processes requiring NAD. and many types of cancer cells boost NAD making enzymes. At the present time it's not been proven ( as far as I can tell) whether supplementing NAD will make cancer cells grow faster and metastasize but it is thought that it does by some. I for one am not going to risk it.

I just thought I would share in case people were unaware and to read up and make their own decisions.

I'm also of the camp that believes we should get most of our vitamins,etc from whole foods. I feel that supplementing most things isn't ideal because it's all a balance. It just makes sense that too much of one thing could throw off that balance. Also the number of things we could supplement is mind boggling, picking and choosing between them seems like such a crapshoot.

Re: TruNiagen???

NeNe1010 — Thu, 12 Jan 2023 01:31:20 GMT

I take it. It's believed that aging is caused by fraying of the telemeres. It supposedly helps repair the frayed ends. Also, they are selling the original version on ShopHQ. The new version also has Tumeric & Vitamin C.

Re: CAREFUL with this supplement .....

febe1 — Thu, 12 Jan 2023 16:00:17 GMT

Yes, I'm on my seventh day, and I have already noticed enery increase. I started feeling like doing a lot of things, which I haven't felt for a long well.

Niagen depletes with age and by 70, almost zero!

Haven't noticed sleep yet, but I ordered his CB Sleeping cream. I hope Danny hasn't exagerated, bC I am hopeful for it. Also, sorry I just ordered 30 and should have gone for 90. Glad to hear of all the improvements!!!

Re: CAREFUL with this supplement .....

SandGirl — Thu, 12 Jan 2023 17:50:52 GMT

Is this the same type of product they recommend to take to help prevent possible skin cancers? B3 I think it is what Derms recommend to take?

Re: CAREFUL with this supplement .....

febe1 — Fri, 13 Jan 2023 20:05:31 GMT

Reported the only other one way with food that you can get Niagen is cows milk. And the amount needed no one could ever consume.

Re: CAREFUL with this supplement .....

granddi — Sat, 14 Jan 2023 03:21:09 GMT

@SandGirl wrote:
Is this the same type of product they recommend to take to help prevent possible skin cancers? B3 I think it is what Derms recommend to take?

Clinical Trial

N Engl J Med

. 2015 Oct 22;373(17):1618-26.

doi: 10.1056/NEJMoa1506197.

A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention

Andrew C Chen 1, Andrew J Martin, Bonita Choy, Pablo Fernández-Peñas, Robyn A Dalziell, Catriona A McKenzie, Richard A Scolyer, Haryana M Dhillon, Janette L Vardy, Anne Kricker, Gayathri St George, Niranthari Chinniah, Gary M Halliday, Diona L Damian

Affiliations expand

PMID: 26488693
DOI: 10.1056/NEJMoa1506197

Free article

Abstract

Background: Nonmelanoma skin cancers, such as basal-cell carcinoma and squamous-cell carcinoma, are common cancers that are caused principally by ultraviolet (UV) radiation. Nicotinamide (vitamin B3) has been shown to have protective effects against damage caused by UV radiation and to reduce the rate of new premalignant actinic keratoses

Re: TruNiagen???

NYCLatinaMe — Tue, 07 Feb 2023 23:23:26 GMT

I am going to try this. Ordered from Amazon. Thanks for bringing it to my attention.

Re: TruNiagen???

NYCLatinaMe — Sun, 12 Feb 2023 17:00:30 GMT

@pdxlalesley Do you take 1 100mg capsule or 1 300mg capsule a day? I don't watch ShopHQ and am uncertain about the appropriate dosage.

@NeNe1010 @febe1 @SeaMaiden and anyone else taking it -- I would also love to hear what dosage you are taking and the reason. And results if any yet!

TIA!

Re: TruNiagen???

Shelbelle — Sun, 12 Feb 2023 17:24:10 GMT

If I was going to take it, I would take the same exact dosage recommended by Tru Niagen and buy the exact same product as far as the ingredients.